Alastin HA IMMERSE Serum™

Most hyaluronic acid serums do one thing: they temporarily attract water to the skin's surface. When you stop using them, the effect stops. Alastin HA IMMERSE Serum does something more interesting. Alongside immediate multi-depth hydration from three molecular weights of Hyaluronic Acid, it contains Octapeptide-45, a peptide that signals the skin to upregulate its own natural Hyaluronic Acid production over time. The result is a serum that improves skin hydration capacity progressively rather than simply masking dehydration temporarily.

Formulated with TriHex Technology alongside the HA and peptide complex, HA IMMERSE also supports collagen and elastin production, making it a hydration serum that simultaneously contributes to structural skin health. Multiple award-winner. Fragrance-free. Suitable for all skin types including sensitive skin.

Who Is It For?

• Dehydrated, dry or dull skin needing immediate and long-term hydration improvement
• Menopausal skin experiencing reduced natural Hyaluronic Acid production
• Patients on GLP-1 medications experiencing increased skin dryness during weight loss
• Those wanting to complement or extend the results of skin booster and polynucleotide injectable treatments
• Post-procedure skin needing intensive hydration support during recovery
• Those wanting a hydration serum that also contributes to structural skin renewal
• Sensitive skin needing a gentle, fragrance-free hydration step

How Does It Work?

HA IMMERSE works at three levels simultaneously. At the surface, low molecular weight Hyaluronic Acid penetrates the stratum corneum to hydrate the upper skin layers. In the mid-layers, medium molecular weight HA attracts and binds water for sustained hydration throughout the day. At the deeper level, Octapeptide-45 signals fibroblasts to increase endogenous Hyaluronic Acid production, building the skin's own long-term hydration capacity from within. TriHex Technology runs alongside all three phases, supporting the clearance of degraded structural proteins and stimulating new collagen and elastin synthesis.

Key Ingredients

• Triple-weight Hyaluronic Acid complex (low, medium and high molecular weight): Each molecular size reaches a different depth in the skin. Together they provide immediate surface hydration, sustained mid-layer moisture binding, and a film-forming surface plumping effect that collectively produces more complete and lasting hydration than single-weight HA serums.
• Octapeptide-45: A peptide unique to this formulation that signals skin fibroblasts to increase their production of endogenous Hyaluronic Acid over time. This is the ingredient that distinguishes HA IMMERSE from standard HA serums by building long-term hydration capacity rather than simply masking dehydration temporarily.
• TriHex Technology (proprietary peptide complex): Clears degraded collagen and elastin from the dermis and stimulates new structural protein production, adding a structural renewal dimension to the hydration serum's activity.
• Niacinamide: Strengthens the skin barrier, reduces transepidermal water loss, calms inflammation and improves overall skin quality throughout the hydration process.

Benefits

• Immediate multi-depth hydration from the first application
• Progressive improvement in the skin's own Hyaluronic Acid production over time
• Reduced transepidermal water loss for more sustained daily hydration
• Visible plumping and reduction in fine dehydration lines
• Structural renewal support from TriHex Technology alongside hydration
• Suitable for all skin types including sensitive and post-procedure skin
• Fragrance-free and non-comedogenic
• Multiple award-winner

What Results Can You Expect?

Immediately: noticeably more hydrated, plumper and more comfortable skin from the first application. At 2 weeks: progressive improvement in skin moisture levels and reduction in dehydration fine lines with consistent use. At 6 weeks: measurable improvement in the skin's hydration capacity as Octapeptide-45 begins to increase endogenous HA production. At 3 months: significantly improved baseline skin hydration that persists beyond individual applications, reflecting the increase in the skin's own HA production capacity.

How We Use It at Face for Soul

As a pharmacist prescriber specialising in skin health, HA IMMERSE is the Alastin hydration serum I recommend most consistently for patients whose skin is chronically dehydrated rather than simply dry. The Octapeptide-45 component is what elevates it above standard HA serums and makes it particularly relevant for menopausal patients, whose natural HA production has declined significantly, and for patients on GLP-1 medications who are experiencing increased skin dryness during weight loss. I also recommend it alongside polynucleotide and skin booster injectable treatments, where supporting the skin's HA production between sessions extends the hydration benefit of those treatments.

How to Use

Apply 3 to 5 drops to clean, slightly damp skin morning and evening before moisturiser. Applying to slightly damp skin maximises the Hyaluronic Acid's ability to attract and bind moisture. Allow to absorb, then apply Alastin Ultra Nourishing Moisturizer to seal in the hydration. Pair with: Alastin Ultra Nourishing Moisturizer, Alastin Restorative Skin Complex, and SPF in the morning. No specific products to avoid. Can be layered comfortably with all Alastin products and most other skincare.

Frequently Asked Questions

Is it worth the money?
HA IMMERSE is the only Hyaluronic Acid serum with a peptide specifically formulated to increase the skin's own HA production over time. Standard HA serums provide temporary hydration and nothing more. If you are dealing with chronic dehydration or significantly reduced skin moisture capacity, the Octapeptide-45 mechanism justifies the price difference over a standard HA serum.

Can I use it with tretinoin?
Yes. Apply HA IMMERSE in the evening after tretinoin has been applied and has absorbed. The Hyaluronic Acid and Niacinamide in HA IMMERSE help offset the dryness that tretinoin commonly causes. This combination is one of the most effective approaches to supporting skin comfort during tretinoin treatment.

Is it pregnancy safe?
HA IMMERSE does not contain retinoids or ingredients with established pregnancy contraindications. We always recommend consulting your midwife or obstetrician before starting new skincare during pregnancy.

Is it suitable for rosacea-prone skin?
Yes. HA IMMERSE is fragrance-free, alcohol-free and contains Niacinamide, which reduces inflammation and redness. It is one of the most rosacea-compatible hydration serums in the Alastin range.

Can I use it after microneedling?
Yes. Hyaluronic Acid serums are generally well tolerated in the early post-microneedling recovery period. HA IMMERSE is gentle enough for use from 24 to 48 hours post-procedure, as directed by your clinician, and the hydration it provides directly supports comfortable recovery.

Can I combine it with Vitamin C?
Yes. Apply Alastin C-RADICAL Defense first in the morning, allow to absorb, then apply HA IMMERSE. The two are fully compatible and complementary.

Does it clog pores?
No. HA IMMERSE is non-comedogenic and suitable for all skin types including oily and acne-prone skin.

How long will one bottle last?
A 30ml bottle used twice daily on the face and neck typically lasts 6 to 8 weeks.

Is it better than a standard HA serum?
For patients with chronic dehydration or reduced HA production capacity, yes. The Octapeptide-45 component adds a progressive improvement in hydration capacity that standard HA serums cannot provide. For patients who simply need surface hydration, a standard HA serum is adequate. The question is whether you want temporary masking or long-term improvement.

Is it vegan?
Yes. Alastin HA IMMERSE Serum is formulated without animal-derived ingredients.

Is it cruelty-free?
Yes. Alastin does not test on animals.

Clinical Insight

As a pharmacist prescriber specialising in skin health, I recommend HA IMMERSE when a patient's skin is chronically dehydrated in a way that standard moisturisers are not adequately addressing. The Octapeptide-45 mechanism is the differentiator. For menopausal patients and for patients on GLP-1 medications, building the skin's own HA production capacity over time is significantly more valuable than temporary surface hydration. This is the serum I pair with skin booster injectable treatments to extend their effects between sessions.

Research and Evidence

The triple-weight Hyaluronic Acid approach is supported by established dermatological research on differential HA molecular weight penetration and action. Octapeptide-45 is a proprietary peptide developed by Alastin and supported by in vitro and clinical data confirming its ability to upregulate fibroblast HA production over time. TriHex Technology is supported by multiple independent published studies on collagen and elastin clearance and synthesis stimulation.

How Does It Compare?

HA IMMERSE vs standard single-weight HA serum: Standard HA serums hydrate the surface temporarily. HA IMMERSE provides multi-depth hydration and, through Octapeptide-45, progressively builds the skin's own HA production capacity. Not the same product at different price points. Genuinely different mechanisms.

HA IMMERSE vs Alastin Ultra Nourishing Moisturizer: HA IMMERSE is the hydration serum applied first to damp skin for deep HA delivery. The Ultra Nourishing Moisturizer is the moisturising step applied after to seal in the hydration and provide barrier support. They are designed to be used together as sequential steps.

HA IMMERSE vs dermal skin boosters: Polynucleotides and skin boosters provide injectable HA and growth factor support at a depth topical products cannot reach. HA IMMERSE provides daily topical support between injectable sessions and, through Octapeptide-45, helps the skin maintain the improved hydration capacity that those treatments establish.

Complete Your Routine

Morning: gentle cleanser, Alastin C-RADICAL Defense Antioxidant Serum, Alastin HA IMMERSE Serum applied to slightly damp skin, Alastin Restorative Skin Complex, Alastin Ultra Nourishing Moisturizer, SPF 30 or higher. Evening: gentle cleanser, Alastin HA IMMERSE Serum, Alastin Restorative Skin Complex, Alastin Ultra Nourishing Moisturizer.

Why Buy From Face for Soul?

At Face for Soul, we stock HA IMMERSE because the Octapeptide-45 mechanism makes it genuinely different from the standard Hyaluronic Acid serums that fill the market. As a prescriber who recommends it alongside injectable skin booster treatments, the clinical rationale is clear. We provide personalised advice before you purchase. Contact us if you are unsure whether this or a standard HA serum is the right choice for your skin.