Epicutis Hyvia Creme | Patented Cellular Hydration Cream 50ml

Most moisturisers work on the skin's surface. They coat, they comfort, they temporarily reduce the sensation of tightness. When you stop using them, the effect stops. The Epicutis Hyvia Creme works differently, because the molecule at its centre works differently.

Hyvia is a patented moisturising compound developed exclusively by Signum Biosciences from organic, non-GMO chia seed oil. It is not a botanical extract in the conventional sense. It is a next-generation molecular entity that delivers stable, potent concentrations of omega-3 and omega-6 fatty acids directly to skin cells, where they integrate into membrane phospholipids, improve cellular hydration capacity, reduce inflammatory signalling and visibly improve fine lines in a way that standard plant oils and conventional moisturisers cannot achieve. Used as Step 2 after the Epicutis Lipid Serum, the Hyvia Creme seals in everything the serum has done and adds its own layer of cellular hydration, antioxidant protection and nourishment to complete the Epicutis two-step protocol.

Sumptuous and velvety in texture. Absorbs completely without heaviness. EWG Verified. Fragrance-free. Suitable for all skin types.

Who Is It For?

• Dry, dehydrated or chronically moisture-depleted skin needing cellular hydration rather than surface coating
• Post-procedure recovery alongside the Epicutis Lipid Serum
• Sensitive or reactive skin needing a rich, nourishing daily moisturiser with no irritation risk
• Mature or menopausal skin that has lost moisture, resilience and barrier integrity
• Those on GLP-1 medications experiencing significant dryness and skin quality changes
• Anyone using the Epicutis Lipid Serum as Step 1 who wants to complete the two-step protocol
• Skin exposed to screens, blue light or significant environmental stress daily

How Does It Work?

Hyvia integrates into the phospholipid membranes of skin cells, where it increases the cell's ability to regulate hydration from within rather than simply attracting water to the surface. The omega-3 and omega-6 fatty acids delivered by Hyvia modulate membrane-level inflammatory signalling, reducing the reactivity that drives sensitivity, redness and discomfort. Ferulic Acid provides antioxidant protection against blue light, UV and environmental pollution, protecting the cellular work that Hyvia is doing from ongoing environmental damage. The supporting botanical complex works with Hyvia and Ferulic Acid to soothe, nourish and maintain long-term skin health. Applied immediately after the Lipid Serum, the Creme seals in TSC and DSD at their sites of action and amplifies the overall outcome of the two-product protocol.

Key Ingredients

• Hyvia (patented chia seed oil extract, Signum Biosciences): A novel molecular entity derived from organic non-GMO chia seed oil through a proprietary process that purifies, concentrates and stabilises omega-3 and omega-6 fatty acids for maximum bioavailability in skin cells. It is not standard chia seed oil. It is a specifically engineered molecule designed to integrate into cell membranes and deliver cellular hydration in a way botanical oils cannot achieve. Backed by peer-reviewed scientific publications.
• Ferulic Acid: A powerful antioxidant that provides protection against blue light, UV-induced and environmental oxidative damage. Published dermatological research confirms synergistic antioxidant enhancement when combined with other molecular antioxidants in a formula, making it a clinically rational pairing with the antioxidant activity of TSC from the preceding serum step.
• Responsibly sourced botanical complex: A selection of potent botanicals chosen for their independently documented efficacy in soothing, nourishing and supporting long-term skin health, without synthetic stabilisers, fillers or fragrance.

Benefits

• Delivers cellular hydration that improves the skin's own moisture regulation capacity over time
• Seals in and amplifies the barrier repair activity of the preceding Lipid Serum step
• Reduces inflammation and sensitivity through membrane-level fatty acid modulation
• Visibly improves fine lines with continued use
• Provides antioxidant protection against blue light and environmental stress
• Rich, velvety texture absorbs completely with no greasy or occlusive residue
• EWG Verified. Fragrance-free. Suitable for all skin types

What Results Can You Expect?

Immediately: the skin feels significantly more nourished, comfortable and deeply moisturised after the first application. The velvety texture absorbs without heaviness. At 2 weeks: improved hydration levels and reduced sensitivity with consistent twice-daily use as part of the two-step Epicutis protocol. At 6 weeks: visible improvement in fine lines, skin quality and overall moisture resilience as cellular hydration capacity improves progressively. At 3 months: meaningfully improved baseline hydration that persists between applications, reflecting the cellular-level hydration improvement that Hyvia produces over time.

How We Use It at Face for Soul

As a pharmacist prescriber specialising in skin health, the Hyvia Creme and Lipid Serum are always recommended together as the Epicutis two-step protocol. The serum repairs and protects the barrier. The Creme seals and amplifies everything the serum has done while adding its own cellular hydration, blue light protection and fine line improvement. Used separately, each is excellent. Used together, the cumulative result is meaningfully better than either product alone. I particularly recommend the combination for post-procedure recovery, menopausal patients, GLP-1 patients and anyone whose skin has been compromised by harsh previous skincare.

How to Use

Apply after the Epicutis Lipid Serum, morning and evening. Use a pea-sized amount and press gently into the face and neck. Allow to absorb before applying SPF in the morning. The Creme sits comfortably under SPF without pilling. Pair with: Epicutis Lipid Serum as Step 1, SPF in the morning as the final step, and Epicutis Arctigenin Brightening Treatment between the Serum and Creme if addressing uneven tone. No products to avoid using alongside it.

Frequently Asked Questions

Is it worth the money?
Hyvia is a patented molecule that does not exist in any other moisturiser. Compared to the cost of standard luxury moisturisers that provide surface hydration only, the Hyvia Creme provides cellular-level hydration improvement backed by peer-reviewed science and EWG Verified ingredient transparency. Yes, it is worth the money.

What makes Hyvia different from standard chia seed oil?
Standard chia seed oil is a plant oil that provides surface nourishment. Hyvia is a purified, concentrated molecular extract developed through a proprietary process that makes omega-3 and omega-6 fatty acids bioavailable at the cellular membrane level. The difference in mechanism and outcome is significant. It is the same relationship as between a whole fruit and a purified pharmaceutical derived from that fruit.

Can I use it with tretinoin?
Yes. Apply tretinoin in the evening first, allow to absorb, then apply the Lipid Serum followed by the Hyvia Creme. The combination of TSC and Hyvia together provides outstanding barrier and hydration support during tretinoin treatment, significantly improving tolerability without interfering with tretinoin's activity.

Is it pregnancy safe?
Yes. The Hyvia Creme contains no retinoids, hydroquinone or ingredients with established pregnancy contraindications. It is one of the safest and most effective moisturisers available during pregnancy.

Is it suitable for rosacea-prone skin?
Yes. The formula is fragrance-free and free from all known rosacea triggers. The membrane-level anti-inflammatory mechanism of Hyvia directly supports the skin stability that rosacea-prone skin needs. It is one of the most appropriate daily moisturisers for this skin type.

Can I use it after microneedling?
Yes. As part of the Epicutis two-step protocol, the Hyvia Creme seals in the Lipid Serum's barrier-repairing activity and provides cellular hydration and nourishment throughout the post-microneedling recovery period. Always follow your clinician's specific post-treatment instructions.

Does it clog pores?
No. The Hyvia Creme is non-comedogenic. The velvety texture absorbs fully without leaving an occlusive or pore-blocking residue.

How long will one tube last?
A 50ml tube used twice daily on the face and neck typically lasts 6 to 8 weeks.

Is it suitable on GLP-1 medication?
Yes. It is one of the most effective daily moisturisers for patients experiencing significant dryness and skin quality changes from GLP-1 medications. The cellular hydration from Hyvia addresses the underlying moisture deficit rather than simply coating the surface.

Is it EWG Verified?
Yes. Epicutis is the only fully EWG Verified professional skincare brand. Every ingredient in the Hyvia Creme has been reviewed and approved by the Environmental Working Group.

Is it vegan?
Yes. The Epicutis Hyvia Creme is formulated without animal-derived ingredients.

Is it cruelty-free?
Yes. Epicutis does not test on animals.

Clinical Insight

As a pharmacist prescriber specialising in skin health, the Hyvia Creme is the moisturiser I recommend when a patient needs more than surface hydration. The cellular mechanism of Hyvia produces a qualitatively different outcome from standard moisturisers over time, and used as Step 2 after the Lipid Serum it completes the most scientifically credible two-step barrier and hydration protocol available in professional skincare. For menopausal patients, GLP-1 patients and post-procedure patients, the combination of TSC and Hyvia working together is the foundation I build every other skin recommendation on top of.

Research and Evidence

Hyvia has been validated through peer-reviewed scientific publications confirming its mechanism of cellular fatty acid delivery and membrane integration. Independent research confirms omega-3 and omega-6 fatty acid modulation of membrane-level inflammatory signalling. Ferulic Acid's antioxidant synergy is documented in published dermatological research. All Epicutis research is published in peer-reviewed journals. EWG Verified status confirms complete ingredient safety and transparency for every component of the formula.

How Does It Compare?

Hyvia Creme vs standard luxury moisturiser: Standard moisturisers hydrate the surface through humectants and occlusives. Hyvia Creme improves the cell's ability to regulate hydration from within through membrane fatty acid integration. Different mechanism, different long-term outcome.

Hyvia Creme vs Epicutis Lipid Serum: The Lipid Serum is Step 1, rebuilding and protecting the barrier through TSC and DSD. The Hyvia Creme is Step 2, sealing in and amplifying the serum's benefits while adding cellular hydration, blue light protection and fine line improvement. The two are designed to be used together.

Hyvia Creme vs Alastin Ultra Nourishing Moisturizer: Alastin uses TriHex Technology for structural collagen and elastin renewal alongside moisturisation. Epicutis uses Hyvia for cellular hydration alongside barrier sealing. They address different biological targets and represent different priorities in a moisturising step. For patients combining both brands, either can work as the moisturising step depending on the individual's primary skin concern.

Complete Your Routine

Morning: Epicutis Oil Cleanser, Epicutis Lipid Serum, Epicutis Hyvia Creme, SPF 30 or higher. Evening: Epicutis Oil Cleanser, Epicutis Lipid Serum, Epicutis Arctigenin Brightening Treatment (if required), Epicutis Hyvia Creme. Weekly intensive: Epicutis Lipid Recovery Mask after Step 1 and before Step 2, 2 to 3 times per week.

Why Buy From Face for Soul?

At Face for Soul, every product we stock is recommended on the basis of clinical evidence. The Epicutis Hyvia Creme is stocked because the patented Hyvia molecule provides a level of cellular hydration that no standard moisturiser ingredient can replicate. As a prescriber who recommends it to patients post-procedure, during GLP-1 treatment and for chronically dry and reactive skin, the results it produces are consistently outstanding. We provide personalised advice before you purchase. Contact us before ordering if you have questions.