Exuviance® AGE REVERSE+ Advanced Total Correct Serum

Skin ageing is not a single problem. It is multiple converging biological changes happening simultaneously. Collagen production declining. Elastin degrading. Cell turnover slowing. Pigmentation accumulating. Barrier function compromising. A serum that addresses only one of these mechanisms produces partial results. A serum that addresses all of them produces transformation.

Exuviance AGE REVERSE Advanced Total Correct Serum is the treatment foundation of the AGE REVERSE protocol. Using breakthrough MicroDiPeptide229 Technology alongside Bakuchiol, NeoGlucosamine, CitraFill and Apple Stem Cell Extract, it targets firmness, texture, pigmentation, wrinkles and overall skin quality in a single concentrated daily formula. Visible improvements in 2 to 4 weeks. Significant improvements across multiple signs of ageing in 8 to 12 weeks of consistent use.

Who Is It For?

• Those wanting a single serum that addresses multiple signs of ageing comprehensively
• Significant loss of firmness, skin laxity and deep established wrinkles
• Uneven skin tone, dark spots and accumulated photodamage
• Mature or menopausal skin needing intensive multi-mechanism anti-ageing renewal
• Those on GLP-1 medications experiencing accelerated skin laxity and quality changes
• Those wanting the most advanced treatment step in the AGE REVERSE range
• Those wanting Bakuchiol-based retinol-alternative renewal without retinol management requirements

How Does It Work?

MicroDiPeptide229 works at the skin's structural matrix level, stimulating simultaneous production of collagen, hyaluronic acid and elastin to firm, hydrate and restore elasticity from within the dermis. Bakuchiol activates the same cellular renewal pathways as retinol at the epidermal level but without the irritation, sun sensitivity or pregnancy contraindications of retinoids. NeoGlucosamine gently exfoliates the surface, promotes cell turnover and targets the pigmentation that makes skin look uneven and aged. CitraFill supports the skin's collagen support matrix. Apple Stem Cell Extract supports cellular regeneration. The combination addresses more signs of ageing simultaneously than any single-mechanism anti-ageing serum can achieve.

Key Ingredients

• MicroDiPeptide229: A breakthrough targeted peptide that stimulates the skin's structural matrix to produce collagen, hyaluronic acid and elastin simultaneously. More comprehensive than conventional single-pathway peptides, it targets the three primary structural proteins of the dermis in a single active.
• Bakuchiol: A plant-derived compound from Psoralea corylifolia demonstrated in published comparative clinical research to produce retinol-equivalent improvements in fine lines, pigmentation and overall skin quality without retinol's irritation, sun sensitivity or pregnancy contraindications. A clinically validated retinol alternative for patients who cannot or do not want to use retinoids.
• NeoGlucosamine (patented, Exuviance): Gently exfoliates the skin surface, promotes cell turnover and fades dark spots and hyperpigmentation through a patented mechanism distinct from standard AHA exfoliants. Provides ongoing surface renewal alongside the deeper structural work of MicroDiPeptide229 and Bakuchiol.
• CitraFill: Targets the extracellular matrix scaffolding that supports the skin's structural proteins, improving firmness and smoothness at the level where collagen and elastin function rather than simply stimulating their production.
• Apple Stem Cell Extract: Supports cellular regeneration and helps preserve the biological vitality of ageing skin cells throughout the multi-mechanism renewal process.

Benefits

• Addresses multiple signs of ageing simultaneously through five distinct mechanisms
• MicroDiPeptide229 firms the skin by stimulating collagen, hyaluronic acid and elastin production
• Bakuchiol provides retinol-equivalent cellular renewal without retinol irritation or sun sensitivity
• NeoGlucosamine corrects uneven tone and dark spots
• CitraFill improves the structural matrix that determines overall skin firmness
• Visible results in 2 to 4 weeks, significant improvement in 8 to 12 weeks
• Appropriate for sensitive skin that cannot tolerate retinol

What Results Can You Expect?

At 2 to 4 weeks: improved skin texture, firmness and early radiance improvements with consistent twice-daily use. At 8 weeks: visible improvements in skin laxity, deep wrinkle depth and pigmentation. At 12 weeks: significant and comprehensive improvement across multiple signs of ageing as all five mechanisms accumulate their effects.

How We Use It at Face for Soul

As a pharmacist prescriber specialising in skin health, Advanced Total Correct Serum is the treatment step I recommend for patients who want the most comprehensive anti-ageing results from the AGE REVERSE range. The multi-mechanism approach addresses more signs of ageing simultaneously than any single-ingredient serum, and the Bakuchiol inclusion makes it particularly valuable for patients who cannot tolerate retinol or who want the cellular renewal benefits without the management requirements of prescription or high-strength retinoids.

How to Use

Apply to cleansed and toned skin on the face and neck morning and evening before moisturiser. Smooth gently and allow to absorb before the next step. Pair with: Exuviance AGE REVERSE BioActiv Wash as the preceding cleanser, Exuviance HydraPrep Toner as the preceding toner, Exuviance AGE REVERSE Total 360 Eye Contour for the eye area, and Exuviance AGE REVERSE HydraFirm or Rebuild-5 Cream as the following moisturiser step. In the morning, follow with Exuviance AGE REVERSE Day Repair SPF 30 as the final step.

Frequently Asked Questions

Is it worth the money?
Advanced Total Correct Serum combines five anti-ageing mechanisms including breakthrough MicroDiPeptide229 Technology in a single daily formula. Achieving equivalent breadth of action through separate targeted serums would require multiple additional steps and a significantly higher total cost. As the treatment foundation of the AGE REVERSE protocol, it is the most efficient single investment in this range.

Can I use it with tretinoin?
The Bakuchiol in this formula provides retinol-equivalent renewal without requiring additional retinoid layering. If you are on a tretinoin programme, you do not need to also use Bakuchiol. Advanced Total Correct Serum can be used in the morning alongside evening tretinoin use.

Is it pregnancy safe?
This serum contains Bakuchiol, which is generally considered among the safer retinol alternatives during pregnancy, but we always recommend consulting your midwife or obstetrician before starting new skincare during pregnancy.

Is it suitable for rosacea-prone skin?
Yes. The Bakuchiol provides cellular renewal without the irritation that makes retinol products unsuitable for many rosacea patients. The formula is fragrance-free and formulated without common rosacea triggers.

Can I use it after microneedling?
Wait until your clinician confirms actives can be reintroduced, typically 5 to 7 days. The Bakuchiol content makes this a gentler reintroduction option than retinol-containing serums for post-microneedling skin.

Can I combine it with Vitamin C?
Yes. Apply a Vitamin C serum first in the morning, allow to absorb, then apply Advanced Total Correct Serum. The antioxidant protection from Vitamin C complements the multi-mechanism renewal of this serum.

Does it clog pores?
No. The formula is non-comedogenic and suitable for all skin types.

How long will one tube last?
Used twice daily on the face and neck, a tube typically lasts 6 to 8 weeks.

Is it suitable on GLP-1 medication?
Yes. The multi-mechanism approach is particularly valuable for patients experiencing accelerated skin ageing and quality changes alongside GLP-1 weight loss.

Is it vegan?
Please contact us to confirm vegan status for this specific product as Exuviance formulations can vary.

Is it cruelty-free?
Yes. Exuviance does not test on animals.

Clinical Insight

As a pharmacist prescriber specialising in skin health, Advanced Total Correct Serum is the serum I recommend when a patient wants comprehensive anti-ageing results and cannot commit to a multi-serum layering routine. MicroDiPeptide229's simultaneous stimulation of collagen, hyaluronic acid and elastin production is the most comprehensive single-peptide structural approach I have encountered in a professional skincare serum. Combined with Bakuchiol, NeoGlucosamine and CitraFill, it addresses more signs of ageing in a single formula than most multi-step protocols.

Research and Evidence

Bakuchiol's retinol-equivalent efficacy is supported by published comparative clinical research, including a double-blind, randomised clinical trial comparing Bakuchiol 0.5% to Retinol 0.5% confirming equivalent fine line and pigmentation improvement. NeoGlucosamine is a patented Exuviance molecule with published evidence of cell turnover promotion and pigmentation improvement. MicroDiPeptide229 is supported by Exuviance's proprietary research confirming stimulation of multiple extracellular matrix components.

How Does It Compare?

Advanced Total Correct Serum vs a standalone retinol serum: Standard retinol serums address one primary mechanism. Advanced Total Correct Serum addresses five simultaneously through MicroDiPeptide229, Bakuchiol, NeoGlucosamine, CitraFill and Apple Stem Cell Extract. For patients wanting comprehensive multi-mechanism anti-ageing, the multi-technology approach produces broader results.

Advanced Total Correct Serum vs Alastin Restorative Skin Complex: Alastin uses TriHex Technology for clearance of degraded structural proteins and stimulation of new collagen and elastin. Exuviance uses MicroDiPeptide229 for direct structural matrix stimulation alongside four additional mechanisms. Both are among the most comprehensive anti-ageing serums available. The choice depends on which broader skincare brand suits the patient's complete routine.

Advanced Total Correct Serum vs skinbetter science AlphaRet Overnight Cream: AlphaRet is a specific retinoid and lactic acid conjugate serum for overnight retinoid renewal. Advanced Total Correct Serum provides broader multi-mechanism daily renewal through MicroDiPeptide229, Bakuchiol and three additional technologies. They address the same general concern through different specific approaches.

Complete Your Routine

Morning: Exuviance AGE REVERSE BioActiv Wash, Exuviance HydraPrep Toner, Exuviance AGE REVERSE Advanced Total Correct Serum, Exuviance AGE REVERSE Total 360 Eye Contour, Exuviance AGE REVERSE HydraFirm, Exuviance AGE REVERSE Day Repair SPF 30. Evening: same cleanser and toner, Advanced Total Correct Serum, eye contour, Exuviance AGE REVERSE HydraFirm or Rebuild-5 Cream, Exuviance AGE REVERSE Advanced Toning Neck Cream on the neck.

Why Buy From Face for Soul?

At Face for Soul, we stock Advanced Total Correct Serum because MicroDiPeptide229 Technology represents the most comprehensive structural approach to anti-ageing renewal we have evaluated in a professional skincare serum, and Bakuchiol makes its cellular renewal benefits accessible to patients who cannot use retinoids. As a prescriber who recommends it across a wide range of patients with different tolerance profiles, the consistency of results it produces is genuinely impressive. Contact us before ordering if you have questions about how it fits into your current routine.