Exuviance® AGE REVERSE+ Rebuild-5 Cream

Most night creams make a single promise. They hydrate, or they firm, or they resurface. Mature skin that has lost collagen, elastin, moisture and surface clarity simultaneously cannot be meaningfully addressed by a product targeting one mechanism. Exuviance AGE REVERSE Rebuild-5 Cream was developed to address all of them simultaneously.

Five skin-rebuilding technologies in a single rich overnight formula: PHAs for gentle resurfacing and barrier support, Peptides for collagen-stimulated firming, Retinol for accelerated cellular turnover, NeoGlucosamine for exfoliation and brightening, and CitraFill for collagen support matrix improvement. Together they produce comprehensive overnight renewal, firming, resurfacing and brightening that no single-mechanism night cream can replicate. For mature, dry or significantly ageing skin that wants maximum results from a single evening moisturiser, this is the most advanced option in the AGE REVERSE range.

Who Is It For?

• Mature or menopausal skin wanting intensive overnight anti-ageing renewal across all visible signs
• Those wanting maximum results from a single evening moisturiser
• Dry skin needing rich nourishment alongside comprehensive active anti-ageing benefits
• Those on GLP-1 medications experiencing skin laxity, dryness and significant skin quality changes
• Anyone who has found lighter night creams insufficient for their skin's needs
• Those comfortable with retinol and wanting the most intensive overnight renewal the AGE REVERSE range offers

How Does It Work?

The five technologies in Rebuild-5 work through five distinct biological mechanisms simultaneously. PHAs provide overnight gentle resurfacing, clearing dead cell accumulation and improving light reflection without barrier disruption. Peptides stimulate fibroblast collagen synthesis in the dermis, rebuilding structural firmness from within. Retinol accelerates epidermal cellular turnover, speeds surface renewal and reduces fine lines while simultaneously stimulating collagen at a second pathway. NeoGlucosamine provides additional surface exfoliation and fades pigmentation. CitraFill supports the skin's collagen structural matrix, improving firmness and smoothness. Shea Butter and Vitamin E maintain nourishment and barrier comfort throughout the overnight renewal cycle.

Key Ingredients

• PHAs (Gluconolactone and Lactobionic Acid): Gently resurface and renew the skin overnight without irritation or sun sensitivity. Support the moisture barrier as they exfoliate, making the combined five-technology formula more tolerable than standard retinol-only night creams.
• Peptides: Signal fibroblasts in the dermis to produce new collagen, improving structural firmness and reducing the depth of established wrinkles with consistent nightly use.
• Retinol: Accelerates epidermal cellular turnover, smooths surface texture, reduces fine lines and stimulates collagen production through a second mechanism alongside the peptide complex. The most clinically studied anti-ageing topical ingredient.
• NeoGlucosamine (patented, Exuviance): Promotes cell turnover, fades dark spots and improves skin clarity through a patented mechanism different from standard AHA exfoliants.
• CitraFill: Targets the skin's collagen support matrix to improve the structural scaffolding that determines overall skin firmness and smoothness.
• Shea Butter and Vitamin E: Nourish and condition the skin, providing barrier comfort that makes the five-technology formula appropriate for dry and mature skin despite its active ingredient density.

Benefits

• Five distinct biological mechanisms addressing ageing simultaneously in a single overnight step
• Retinol-driven cellular turnover acceleration for maximum surface renewal
• Peptide-stimulated collagen synthesis for improved structural firmness
• NeoGlucosamine pigmentation correction and brightening
• CitraFill collagen matrix support
• PHA gentle resurfacing and barrier support alongside the active complex
• Rich, nourishing texture appropriate for dry and mature skin

What Results Can You Expect?

Immediately: skin feels deeply nourished and well-treated from the first application. At 2 to 4 weeks: improved skin texture, hydration and early radiance improvements with consistent nightly use. At 8 to 12 weeks: visible improvements in skin firmness, deep wrinkle depth, tone evenness and overall skin quality as the five technologies' combined effects accumulate. The five-mechanism approach means results are more comprehensive and faster than single-ingredient night creams of comparable price.

How We Use It at Face for Soul

As a pharmacist prescriber specialising in skin health, Rebuild-5 Cream is the evening moisturiser I recommend for patients in the AGE REVERSE routine who have dry or mature skin and want the most intensive overnight renewal the range delivers. For patients who have previously found that night creams produce insufficient change in their skin, the five-technology combination addresses why: single-mechanism products cannot replicate the cumulative effect of five distinct renewal pathways working simultaneously throughout the night.

How to Use

Apply to cleansed skin on the face and neck each evening as the final step. Follow your cleanser, toner and treatment serums before applying. No rinsing required. Always apply SPF 30 or higher the following morning. Pair with: Exuviance AGE REVERSE Advanced Total Correct Serum as the preceding treatment serum, Exuviance AGE REVERSE Total 360 Eye Contour before this moisturiser, and Exuviance AGE REVERSE Advanced Toning Neck Cream as a dedicated neck step. In the morning, replace with Exuviance AGE REVERSE Day Repair SPF 30.

Frequently Asked Questions

Is it worth the money?
Rebuild-5 Cream delivers five clinically active rebuilding technologies in a single evening step. Achieving equivalent results through separate products would require a peptide serum, a retinol serum, a PHA exfoliant and a collagen support treatment. The clinical efficiency of combining all five in one formula makes it exceptional value for mature and dry skin that needs comprehensive overnight renewal.

Can I use it with tretinoin?
This formula contains Retinol. If you are using prescription tretinoin, you do not need additional retinol in your routine. For patients on tretinoin, consider using the Exuviance AGE REVERSE HydraFirm in the evening instead, which provides the other AGE REVERSE technologies without additional retinol.

Is it pregnancy safe?
This formula contains Retinol. We do not recommend retinol products during pregnancy. Please consult your midwife or obstetrician.

Is it suitable for rosacea-prone skin?
The Retinol content means it may not be appropriate for actively flaring rosacea-prone skin. Start with 2 nights per week and build up tolerance gradually. For rosacea-prone skin wanting a gentler option, the Overnight Transformation Complex provides renewal without retinol.

Can I use it after microneedling?
Wait until your clinician confirms retinol can be reintroduced, typically 5 to 7 days minimum after microneedling. Always follow your clinician's specific post-treatment instructions on retinol reintroduction timing.

Does it clog pores?
No. The formula is non-comedogenic despite its rich texture.

How long will one tube last?
Used nightly on the face and neck, a tube typically lasts 6 to 8 weeks.

Is it suitable on GLP-1 medication?
Yes. The rich, nourishing formula combined with five active rebuilding technologies makes it well suited to patients experiencing skin laxity and dryness alongside GLP-1 medication use.

Is it vegan?
Please contact us to confirm vegan status for this specific product as Exuviance formulations can vary.

Is it cruelty-free?
Yes. Exuviance does not test on animals.

Clinical Insight

As a pharmacist prescriber specialising in skin health, Rebuild-5 Cream is the recommendation I make when a patient tells me their night cream is not producing visible change. The reason most night creams fail to produce meaningful results is that they address one mechanism. Rebuild-5 addresses five simultaneously. For mature, dry and significantly ageing skin, the five-technology approach produces a qualitatively different level of overnight renewal than any single-mechanism alternative.

Research and Evidence

Retinol's mechanism of cellular turnover acceleration and collagen synthesis stimulation is among the most extensively published in dermatological literature. Peptide-stimulated collagen production is supported by published research on signalling peptides including the Matrixyl family. Gluconolactone and Lactobionic Acid are part of the Exuviance patented PHA and Bionic Acid technology portfolio. NeoGlucosamine is a patented Exuviance molecule. CitraFill's collagen matrix-targeting mechanism is supported by Exuviance's proprietary research.

How Does It Compare?

Rebuild-5 Cream vs Exuviance Overnight Transformation Complex: Overnight Transformation Complex uses PHA and Bionic Acids for gentle overnight renewal without retinol, appropriate for all skin types and for patients who cannot tolerate retinol. Rebuild-5 uses five technologies including retinol for maximum intensive renewal. For maximum results in retinol-tolerant, dry and mature skin, Rebuild-5. For all-skin-types overnight renewal without retinol, Overnight Transformation Complex.

Rebuild-5 Cream vs Exuviance AGE REVERSE HydraFirm: HydraFirm is a day and night moisturiser richer in hydration actives through its NMF complex, without retinol. Rebuild-5 is an evening-only formula with five rebuilding technologies including retinol. For retinol-tolerant patients wanting maximum overnight renewal, Rebuild-5 in the evening and HydraFirm in the morning is the most comprehensive combination.

Rebuild-5 Cream vs skinbetter science AlphaRet Overnight Cream: AlphaRet uses a lactic acid and retinoid conjugate technology that delivers retinol renewal with significantly reduced irritation. Rebuild-5 uses conventional retinol alongside four additional technologies. AlphaRet is the more tolerable option for retinol-sensitive patients. Rebuild-5 provides the broader five-mechanism approach for patients with established retinol tolerance.

Complete Your Routine

Evening: Exuviance AGE REVERSE BioActiv Wash, Exuviance HydraPrep Toner, Exuviance AGE REVERSE Advanced Total Correct Serum, Exuviance AGE REVERSE Total 360 Eye Contour, Exuviance AGE REVERSE Advanced Toning Neck Cream on the neck and decollete, Exuviance AGE REVERSE Rebuild-5 Cream on the face. Morning: cleanser, toner, serum, eye contour, Exuviance AGE REVERSE Day Repair SPF 30.

Why Buy From Face for Soul?

At Face for Soul, we stock Rebuild-5 Cream because mature and significantly ageing skin requires multi-mechanism overnight treatment to see meaningful change and this is the most comprehensive single evening moisturiser we have evaluated for that purpose. As a prescriber who recommends it to patients with mature and dry skin in the AGE REVERSE range, the consistency of results it produces compared to single-mechanism alternatives is notable. Contact us before ordering if you have questions about whether this or the Overnight Transformation Complex is more appropriate for your skin.