iS Clinical Pro-Heal Serum Advance+ | Antioxidant Serum for Compromised & Blemish-Prone Skin

Most antioxidant serums protect the skin from future damage. Pro-Heal Serum Advance+ does that and more: it simultaneously calms inflammation, supports healing in compromised and blemish-prone skin and delivers a combination of stable Vitamins A, C and E alongside Olive Leaf Extract that addresses the underlying biochemistry of both acne and skin ageing at the same time.

It is one of the few antioxidant serums that actively performs on acne-prone and sensitised skin rather than simply sitting on top of it.

Who is Pro-Heal Serum Advance+ best for?

• Compromised, sensitised or barrier-disrupted skin needing antioxidant support
• Blemish-prone and acne-prone skin needing anti-inflammatory correction alongside antioxidant protection
• Post-procedure skin needing soothing antioxidant support during recovery
• Those on GLP-1 medications whose skin may be more reactive and oxidatively stressed during weight loss
• Rosacea-prone skin needing calming alongside daily antioxidant defence
• Anyone whose skin does not tolerate standard Vitamin C serums

Key ingredients and why they matter

• ADVANCE+ Vitamin C (stabilised L-Ascorbic Acid): iS Clinical's proprietary stabilised form of Vitamin C that provides continuous antioxidant protection, collagen synthesis support and brightening without the instability or irritation of standard L-Ascorbic Acid serums
• Olive Leaf Extract: A natural polyphenol antioxidant with clinically documented anti-inflammatory and anti-acneic properties. Reduces the inflammatory signalling that drives both active blemishes and chronic skin sensitivity
• Vitamin E (Tocopherol): Works synergistically with Vitamin C to enhance and extend antioxidant protection
• Vitamin A (Retinyl Palmitate): A gentle form of Vitamin A that supports collagen synthesis, cell turnover and skin renewal without the irritation of prescription retinoids
• Zinc Sulfate: Provides photoprotection, supports wound healing and modulates immune function in the skin

What results can you expect?

Calmer, less reactive and more protected skin from the first use. Blemish frequency and severity reduce progressively over 4 to 8 weeks. With consistent daily use, skin becomes more resilient, more even in tone and better defended against the environmental triggers that cause premature ageing.

How we use Pro-Heal Serum Advance+ at Face for Soul

As a pharmacist prescriber specialising in skin health, Pro-Heal Serum Advance+ is the antioxidant serum I recommend most often for patients with acne-prone or reactive skin who need antioxidant protection but find most Vitamin C serums either too irritating or too active for their compromised barrier. The Olive Leaf Extract is genuinely unusual in this category and clinically meaningful for inflammatory skin conditions.

I also recommend it consistently for post-procedure recovery, where antioxidant protection is needed but the skin cannot tolerate more aggressive formulas, and for patients on GLP-1 medications whose skin tends to become more reactive during periods of significant body composition change.

Complete your iS Clinical routine

Pro-Heal Serum Advance+ works as a morning antioxidant treatment step. Apply after cleansing with the iS Clinical Cleansing Complex, then follow with a moisturiser such as the iS Clinical Moisturizing Complex or Daily Dynamic Hydrator, and finish with iS Clinical Extreme Protect SPF 40 or Eclipse SPF 50+. For the eye area, the iS Clinical Youth Eye Complex or C Eye Serum Advance+ completes the protocol.

Frequently Asked Questions

How does it differ from the Super Serum Advance+?
Super Serum Advance+ uses 15% Vitamin C with Copper Tripeptide-1 and is primarily an anti-ageing and brightening treatment. Pro-Heal Serum Advance+ uses a lower, better-tolerated Vitamin C concentration alongside Olive Leaf Extract for anti-inflammatory and anti-acneic benefits. Pro-Heal is the choice for reactive, blemish-prone and compromised skin; Super Serum is the choice for photodamage, ageing and brightening.

Is it suitable post-procedure?
Yes. The anti-inflammatory Olive Leaf Extract and gentle antioxidant complex make it one of the better-tolerated antioxidant serums for post-procedure use. Always follow your clinician's specific advice on when to restart actives after your treatment.

Is it suitable if I am on GLP-1 medication?
Yes. Patients on GLP-1 medications experiencing increased skin reactivity and sensitivity benefit from the calming, antioxidant-protective approach of Pro-Heal Serum Advance+.

Morning or evening?
Both. Apply morning and evening to clean skin before moisturiser.

Is iS Clinical cruelty-free?
Yes. iS Clinical does not test on animals.

Is it vegan?
iS Clinical formulates without animal-derived ingredients in the majority of its products. Please contact us if you have specific ingredient concerns.

How to Use

Apply to clean skin morning and evening before moisturiser. Follow with SPF in the morning.