iS Clinical Hydra-Cool Serum | Soothing Hydration Serum for All Skin Types

Hydration and calm in one formula. Hydra-Cool Serum is iS Clinical's most universally tolerated serum: a lightweight, refreshing formula that rejuvenates, hydrates and visibly soothes skin that is stressed, sensitised, dehydrated or in need of a calming reset. It is gentle enough for the most reactive skin, effective enough to stand as a dedicated treatment step and versatile enough to be used whenever the skin needs it, morning, evening or both.

Who is Hydra-Cool Serum best for?

• Dehydrated, tight or dull skin needing immediate comfort and hydration
• Sensitive, reactive or rosacea-prone skin needing a soothing daily serum
• Post-procedure skin in the early recovery phase needing gentle hydration support
• Those using high-strength active serums who need a calming hydration step alongside them
• Those on GLP-1 medications experiencing increased skin dryness and sensitivity
• Anyone wanting a serum that provides immediate visible improvement from the first application
• A gentle entry point into iS Clinical for patients new to the brand

Key ingredients and why they matter

• Centella Asiatica (Asiaticoside, Asiatic Acid, Madecassic Acid): One of the most clinically studied wound-healing and anti-inflammatory botanicals in dermatology. Calms inflammation, supports barrier repair and promotes healing in stressed and sensitised skin
• Hyaluronic Acid: Attracts and binds moisture in the skin for immediate and lasting hydration and a visibly plumped, more comfortable complexion
• Botanical antioxidant complex: Protects against free radical damage and environmental stressors while the soothing actives calm and hydrate

What results can you expect?

Immediately calmer, more hydrated and more comfortable skin from the first application. With consistent daily use, skin becomes progressively more resilient, more hydrated and better able to tolerate active treatment products. Post-procedure skin recovers more comfortably when Hydra-Cool Serum is used as part of the early aftercare routine.

How we use Hydra-Cool Serum at Face for Soul

As a pharmacist prescriber specialising in skin health, Hydra-Cool Serum is the iS Clinical product I most commonly recommend as a post-procedure early recovery step and as a daily serum for patients with rosacea or chronically reactive skin who need hydration and calming before they can progress to active correction.

It works particularly well as a base layer under stronger iS Clinical serums for patients whose skin cannot yet tolerate active serums alone. Apply Hydra-Cool Serum first, allow to absorb, then apply the more active serum on top. This layering approach allows patients to benefit from active serums at a higher tolerance than if they were applied directly to dry skin.

Complete your iS Clinical routine

Hydra-Cool Serum fits into any iS Clinical routine as either a standalone hydration step or a calming base layer before more active serums. Apply after the iS Clinical Cleansing Complex, then follow with iS Clinical Moisturizing Complex or SHEALD Recovery Balm for additional barrier support. For post-procedure use, pair with the iS Clinical Hydra-Intensive Cooling Mask 2 to 3 times per week for intensive recovery support.

Frequently Asked Questions

Can I use it at the same time as active serums?
Yes. Apply Hydra-Cool Serum first to damp skin, allow to absorb, then apply your active serum over the top. This sandwich technique reduces the potential for active serums to cause dryness or irritation.

Is it suitable post-procedure?
Yes. It is one of the gentlest and most soothing serums suitable for early post-procedure use. Always follow your clinician's specific post-treatment instructions on when to restart skincare products.

Is it suitable if I am on GLP-1 medication?
Yes. Patients on GLP-1 medications experiencing dryness and increased skin sensitivity benefit directly from the hydrating and calming approach of Hydra-Cool Serum.

Is iS Clinical cruelty-free?
Yes. iS Clinical does not test on animals.

Is it vegan?
iS Clinical formulates without animal-derived ingredients in the majority of its products. Please contact us if you have specific ingredient concerns.

How to Use

Apply to clean skin morning and evening, or whenever skin needs a soothing, hydrating boost. Follow with SPF in the morning.