iS Clinical Retinol+ Emulsion 0.3 | Advanced Botanical Retinol Night Treatment

Retinol rethought from the delivery mechanism up. Where most retinol formulas use synthetic retinol in a standard emulsion base, iS Clinical's Retinol+ Emulsion uses a botanical-origin Retinol encapsulated with bio-identical lipids, Phosphatidylcholine and Triglycerides, for superior delivery directly to its site of action within the skin. A proprietary antioxidant trio of Rice Bran, Rosemary and Vitamin E increases retinol potency by over 30% while acting as a natural preservative system.

The result is faster, more visible anti-ageing results with significantly better skin tolerance than most retinol formulas at equivalent strength, alongside a supporting cast of Bakuchiol, Copper Tripeptide-1, Colloidal Gold, Extremozymes and stabilised Vitamin C that makes this one of the most comprehensively formulated retinol emulsions available.

Who is Retinol+ Emulsion 0.3 best for?

• Those new to retinol wanting a gentle 0.3% starting concentration with exceptional tolerance
• Sensitive skin needing retinol results with reduced irritation risk
• Those wanting a retinol formula that also delivers Copper Tripeptide-1, Extremozymes and Vitamin C in a single evening step
• Those on GLP-1 medications wanting retinol-level skin renewal to address accelerated skin ageing during weight loss
• Post-procedure maintenance once skin has returned to full retinol tolerance
• Those who have previously abandoned retinol due to irritation

Key ingredients and why they matter

• Retinol 0.3% (Botanical Origin, bio-identical lipid encapsulated): Delivered in Phosphatidylcholine and Triglyceride encapsulation for superior penetration and reduced surface irritation compared to standard retinol emulsions
• Bakuchiol: A botanical retinol booster from Ayurvedic medicine with its own independent retinol-like activity that amplifies results and provides additional skin tolerability
• Extremozymes (Ectoin): iS Clinical's patented technology that shields DNA and cells from environmental stressors and supports the skin's recovery during retinol-driven cell turnover
• Copper Tripeptide-1: Clinically proven to stimulate collagen synthesis, supports healing and regeneration alongside the retinol renewal process
• Colloidal Gold: Complexed into a biologically usable form that participates in collagen synthesis
• Vitamin C (stable Ascorbic Acid): Protects against photoageing and delivers brightening activity
• Sodium Hyaluronate and Squalane: Deep hydration and barrier support throughout the renewal process

What results can you expect?

Visible improvements in fine lines, texture, pigmentation and overall skin quality over 8 to 12 weeks of consistent evening use, with significantly fewer tolerance issues than standard retinol formulas at 0.3%. The encapsulation technology produces faster visible results per use than non-encapsulated retinol at equivalent concentration.

How we use Retinol+ Emulsion 0.3 at Face for Soul

As a pharmacist prescriber specialising in skin health, iS Clinical Retinol+ Emulsion 0.3 is the retinol I most frequently recommend as an entry point for patients new to prescription-strength retinoids or those who want retinol-level results without requiring a prescription. The bio-identical lipid encapsulation is clinically meaningful, not just a marketing claim, and the Bakuchiol addition genuinely improves both efficacy and tolerance.

For patients on GLP-1 medications experiencing accelerated skin ageing, cellular turnover support from retinol is one of the most important interventions available outside of prescription tretinoin. This formula allows patients to start retinol correction at the beginning of their weight loss journey at a concentration and in a format that most patients can tolerate consistently.

Build your iS Clinical evening routine around it

Apply Retinol+ Emulsion 0.3 every 3 days for the first 3 weeks, then increase to every 2 days as tolerated. Cleanse with iS Clinical Cleansing Complex, apply the emulsion to dry skin, then follow with iS Clinical Moisturizing Complex or Youth Intensive Crème. Always apply iS Clinical Extreme Protect SPF 40 the following morning. Once full tolerance is established, the iS Clinical Active Serum can be introduced on alternating evenings for clearing and brightening alongside the retinol renewal.

Frequently Asked Questions

Should I use it if I am already using prescription tretinoin?
Tretinoin is more potent than 0.3% retinol and the two should not generally be used simultaneously. If you are already prescribed tretinoin, speak with your prescriber before adding this product.

Is it suitable if I am on GLP-1 medication?
Yes. Retinol-level cellular renewal is one of the most clinically meaningful topical interventions for the accelerated skin ageing that GLP-1 patients experience. The tolerance profile of this formula makes it appropriate even for patients whose skin has become more reactive during weight loss.

Does it increase sun sensitivity?
Yes. Always apply broad-spectrum SPF every morning throughout retinol use without exception.

Is iS Clinical cruelty-free?
Yes. iS Clinical does not test on animals.

Is it vegan?
iS Clinical formulates without animal-derived ingredients in the majority of its products. Please contact us if you have specific ingredient concerns.

How to Use

Apply 2 to 3 pumps to clean, dry skin on the face and neck in the evening. Start every 3 days for the first 3 weeks, then increase to every 2 days or as directed. Always apply broad-spectrum SPF the following morning.