Senté Dermal Repair Ultra Nourish | Intensive Lipid and HSA Repair Cream

When the skin barrier is genuinely compromised, standard moisturisers are not enough. A compromised barrier cannot retain water regardless of how much hydration is applied to the surface. The lipids that form the barrier, ceramides, fatty acids and cholesterol, need to be replenished in a form the skin can actually use, not simply occluded with mineral oil or dimethicone. Senté Dermal Repair Ultra Nourish was developed for exactly this clinical situation: skin that has lost its barrier integrity and is no longer responding adequately to conventional moisturisers, whether from chronic dryness, mature lipid depletion, sensitivity, post-procedure stress or inflammatory skin conditions.

It combines the patented HSA mechanism of the original Dermal Repair Cream with a unique epidermal lipid blend that closely mimics the skin's own barrier lipid composition: ceramides, omega fatty acids 3, 6 and 9, and cholesterol in the ratios that allow them to integrate into the barrier structure rather than simply sit on top of it. The result is genuine barrier reconstruction alongside the HSA anti-inflammatory and deep hydration activity. Works as a daily moisturiser for very dry and mature skin, or as an intensive overnight barrier repair treatment for any skin type.

Who Is It For?

• Very dry, dehydrated and mature skin where standard moisturisers have stopped providing adequate hydration
• Barrier-compromised skin from over-exfoliation, harsh products or chronic irritation
• Menopausal skin with significant lipid depletion and chronic dryness
• Post-procedure skin needing intensive barrier repair after laser, deep peels or resurfacing
• Rosacea-prone and chronically sensitive skin with ongoing inflammatory compromise of the barrier
• Those on GLP-1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) with significant reactive dryness during weight loss
• Anyone wanting the richest, most intensive HSA moisturiser in the Senté range

How Does It Work?

HSA provides the same molecular-level water attraction, collagen activation, inflammatory modulation and cell communication support as in the original Dermal Repair Cream. The epidermal lipid blend provides genuine barrier reconstruction: ceramides restore the lipid bilayer structure, omega fatty acids 3, 6 and 9 replenish essential fatty acid deficiencies, cholesterol provides the structural lipid component in the ratios the barrier requires. Together they address both the inflammatory driver of barrier compromise through HSA and the structural lipid deficit through the biocompatible lipid complex. Acetyl Glucosamine supports hydration and helps improve uneven skin tone over time.

Key Ingredients

• Heparan Sulfate Analog (HSA, patented, Senté): Deep water retention, collagen activation, inflammatory modulation and cell communication support at the molecular level. The same mechanism as in Dermal Repair Cream at a richer formulation base.
• Epidermal Lipid Blend (Ceramides, Omega Fatty Acids 3, 6 and 9, Cholesterol): A biocompatible lipid complex that mimics the skin's own barrier lipid composition in the ratios needed for genuine barrier integration rather than surface-only occlusion. Distinguishes Ultra Nourish from the standard Dermal Repair Cream.
• Acetyl Glucosamine: Skin-identical humectant that supports hydration and helps fade dark spots and uneven tone with consistent use.

Benefits

• Genuine barrier reconstruction through biocompatible lipid replenishment
• Deeply and lastingly hydrates very dry, dehydrated and barrier-compromised skin
• HSA anti-inflammatory activity reduces redness and calms chronic irritation
• Reduces the appearance of fine lines, wrinkles and redness
• Non-comedogenic, hypoallergenic, dermatologist-tested
• Free from parabens, fragrance, dyes, alcohol and soap
• Appropriate as daily moisturiser for very dry skin or overnight intensive treatment for all skin types

What Results Can You Expect?

After first use: significantly more comfortable, nourished skin. At 2 to 4 weeks: meaningful improvement in barrier comfort, reduced tightness and early improvement in redness with consistent use. At 8 weeks: visible improvement in skin quality, hydration retention and redness for barrier-compromised and very dry skin.

How We Use It at Face for Soul

As a pharmacist prescriber specialising in skin health, Dermal Repair Ultra Nourish is the Senté product I prescribe when the original Dermal Repair Cream is not rich enough for the patient's barrier needs. Post-procedure skin after deep laser resurfacing, menopausal skin with significant lipid depletion, and GLP-1 patients with severe reactive dryness are the three groups where I reach for Ultra Nourish over the standard cream. The biocompatible lipid blend is the clinical difference: it provides barrier reconstruction rather than only barrier support, which is the right intervention when the barrier itself is structurally compromised.

How to Use

Apply one pump to clean skin on the face and neck morning and evening. If using with a retinoid, apply tretinoin or retinol first, allow to fully absorb, then apply Ultra Nourish as the sealing moisturiser. For intensive overnight use on any skin type: apply a generous layer as the final evening step after all other products.

Frequently Asked Questions

What is the difference between Dermal Repair Cream and Ultra Nourish?
Both contain HSA as the primary active. Ultra Nourish adds a biocompatible epidermal lipid blend (ceramides, omega fatty acids and cholesterol) for barrier reconstruction, and is a richer formulation. Choose Dermal Repair Cream for most skin types as a daily moisturiser. Choose Ultra Nourish for very dry, mature or barrier-compromised skin, for post-procedure recovery and as an intensive overnight treatment.

Can I use it with tretinoin?
Yes. Apply tretinoin and allow to absorb, then apply Ultra Nourish. The biocompatible lipid blend and HSA provide excellent barrier support during retinoid treatment, reducing adjustment period severity without occluding tretinoin activity.

Is it pregnancy safe?
No established pregnancy contraindications. Consult your midwife or obstetrician.

Is it suitable for rosacea-prone skin?
Yes. HSA's anti-inflammatory mechanism and the fragrance-free, alcohol-free, dye-free formulation make Ultra Nourish appropriate for rosacea-prone skin needing intensive barrier nourishment alongside the inflammatory modulation benefit.

Does it clog pores?
No. Non-comedogenic despite its richness. The biocompatible lipid composition is designed to integrate into the barrier rather than sit on top of it in a pore-blocking way.

Is it suitable for GLP-1 patients?
Yes. Significant reactive dryness and barrier compromise during GLP-1 weight loss is where Ultra Nourish is most appropriate when the standard Dermal Repair Cream is insufficient.

Clinical Insight

As a pharmacist prescriber, the biocompatible epidermal lipid blend in Ultra Nourish is what makes it the clinical choice over the standard Dermal Repair Cream for genuinely compromised barriers. Ceramides, omega fatty acids and cholesterol in the ratios the barrier uses cannot be replaced by surface occlusives. When the barrier itself is structurally depleted, replenishing the lipid components it is missing at the structural level is the correct clinical intervention, not adding more water or humectants on top of a compromised structure.

Research and Evidence

The role of ceramides, essential fatty acids and cholesterol in skin barrier structure and function is among the most published in dermatological science. The importance of the ratio of these lipids in barrier formulations for effective barrier integration rather than surface occlusion is documented in published barrier science research. HSA's anti-inflammatory and deep hydration mechanisms are supported by Senté's clinical research and published literature on Heparan Sulfate in skin biology.

How Does It Compare?

Ultra Nourish vs Senté Dermal Repair Cream: Dermal Repair Cream for daily use on most skin types. Ultra Nourish for very dry, mature or barrier-compromised skin needing the richer lipid replenishment formulation.

Ultra Nourish vs Epicutis Hyvia Creme: Hyvia uses patented Hyvia-HA for chronobiology-aligned hydration. Ultra Nourish uses HSA plus biocompatible epidermal lipids for barrier reconstruction and anti-inflammatory repair. For the most compromised barriers where structural lipid replenishment is the clinical priority, Ultra Nourish. For the most advanced daily hydration and cellular renewal, Hyvia Creme.

Complete Your Routine

Morning: Senté Daily Soothing Cleanser, Senté Hydrate+ Serum or Defense C Serum, Senté Dermal Repair Ultra Nourish, Senté Even Tone Mineral Sunscreen SPF 30. Evening: Senté Daily Soothing Cleanser, treatment serum, Senté Dermal Repair Ultra Nourish (or as intensive overnight step).

Why Buy From Face for Soul?

At Face for Soul, Dermal Repair Ultra Nourish is recommended when the standard Dermal Repair Cream is not sufficient for the patient's barrier needs. As a prescriber managing post-procedure recovery and GLP-1 skin programmes, having the richer lipid-replenishing formulation available makes the difference between adequate and genuinely restorative barrier care. Contact us if you are unsure whether Dermal Repair Cream or Ultra Nourish is the appropriate choice for your skin.